[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amine → Methyl-[3-(3-methyl-1H-indol-5-yl)-3-phenyl-propyl]-amine

HRID 1716679ノート

反応式

HRID 1716679 の反応式
[CH3:1][NH:2][C:3](=O)[CH2:4][CH:5]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16](C)=[CH:15]2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.N1C2C(=CC=CC=2C(C2C=CC=CC=2)CCNC)C=[CH:24]1>>[CH3:1][NH:2][CH2:3][CH2:4][CH:5]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH:16]=[C:15]2[CH3:24])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

3

反応物 2

HCID 17747555[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amineHCID 59831697N-methyl-3-(2-methyl-1H-indol-5-yl)-3-phenyl-propionamide

生成物 1

HCID 25261573Methyl-[3-(3-methyl-1H-indol-5-yl)-3-phenyl-propyl]-amine収率 68%

実験手順

Methyl-[3-(3-methyl-1H-indol-5-yl)-3-phenyl-propyl]-amine LXXIV (221 mg, 68% yield) was prepared from N-methyl-3-(2-methyl-1H-indol-5-yl)-3-phenyl-propionamide using the procedure described above for [3-(1H-indol-7-yl)-3-phenyl-propyl]-methyl-amine XX (see Example 4). MS (M+H)=279.

出典と根拠

ORDレコード
ord-124757f335f34dd099b6748e23b7cb6a
出典データセット
uspto-grants-2010_09
特許番号
US07803830B2

反応ノート

読み込み中…