5-(3-Chlorophenyl)furan-2-carboxylic acid → 5-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester

HRID 1717060

反応式

HRID 1717060 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:18][C:19]([C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH2:30])=[CH:25][CH:24]=2)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[NH:22][C:23]2[C:28]([CH:29]=1)=[CH:27][C:26]([NH:30][C:13]([C:11]1[O:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:9][CH:10]=1)=[O:15])=[CH:25][CH:24]=2)=[O:20])[CH3:17]

参加物

3

反応物 2

HCID 7362565-(3-Chlorophenyl)furan-2-carboxylic acidHCID 10726872Ethyl 5-amino-1H-indole-2-carboxylate

生成物 1

HCID 596546335-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-1H-indole-2-carboxylic acid ethyl ester

実験手順

5-(3-Chloro-phenyl)-furan-2-carboxylic acid (65) (54 mg, 0.24 mmol) was coupled to ethyl ester (58) (50 mg, 0.24 mmol) using Method C. The crude residue was purified by column chromatography eluting with 20% EtOAc in heptane to give the title compound.

後処理

  1. customThe crude residue was purified by column chromatography
  2. washeluting with 20% EtOAc in heptane

出典と根拠

ORDレコード
ord-db417808bbee4a0bb5f7a0bfb632ec27
出典データセット
uspto-grants-2010_09
特許番号
US07803841B2

関連ノート

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