Azido(trimethyl)stannane → HCID 178522031、化合物
反応式
[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]([C:13]2[O:14][C:15]([Br:18])=[CH:16][CH:17]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)#[N:2].[Sn]([N:23]=[N+:24]=[N-:25])(C)(C)C>>[NH:23]1[C:1]([CH2:3][C:4]2[CH:5]=[C:6]([NH:10][C:11]([C:13]3[O:14][C:15]([Br:18])=[CH:16][CH:17]=3)=[O:12])[CH:7]=[CH:8][CH:9]=2)=[N:2][N:25]=[N:24]1参加物
3
実験手順
Nitrile (83) (162 mg, 0.53 mmol) was treated with Me3SnN3 using Method K. The residue was purified by column chromatography, flushing with heptane (200 ml) and eluting with 50% EtOAc in heptane to give the title compound.
後処理
- customThe residue was purified by column chromatography
- customflushing with heptane (200 ml)
- washeluting with 50% EtOAc in heptane
出典と根拠
- ORDレコード
- ord-d984b7d3efdd4c2c938e3809bf181386
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07803841B2
反応ノート
読み込み中…