1-Bromo-2-Chloroethane → 1-{2-(2-chloroethoxy)-4-[(ethylamino)carbonyl]phenyl}-N-cyclopropyl-5-methyl-1H-1,2,3-triazole-4-carboxamide
反応式
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([NH:21][CH2:22][CH3:23])=[O:20])=[CH:15][C:14]=3[OH:24])[C:11]=2[CH3:12])=[O:6])[CH2:3][CH2:2]1.Br[CH2:26][CH2:27][Cl:28]>C(OCC)(=O)C.CCCCCC>[Cl:28][CH2:27][CH2:26][O:24][C:14]1[CH:15]=[C:16]([C:19]([NH:21][CH2:22][CH3:23])=[O:20])[CH:17]=[CH:18][C:13]=1[N:10]1[C:11]([CH3:12])=[C:7]([C:5]([NH:4][CH:1]2[CH2:3][CH2:2]2)=[O:6])[N:8]=[N:9]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
In the same manner as in Example 145, a product was obtained from N-cyclopropyl-1-{4-[(ethylamino)carbonyl]-2-hydroxyphenyl}-5-methyl-1H-1,2,3-triazole-4-carboxamide (0.17 g) obtained in Example 141 and 1-bromo-2-chloroethane (0.05 ml), and the title compound was obtained as a white powder (0.06 g, 31%) by recrystallization from ethyl acetate-hexane.