Calcium Chloride → 3-(4-isopropoxyphenyl)-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one

HRID 1718429ノート

反応式

HRID 1718429 の反応式
[Na].[CH:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:17](=[O:18])[C:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[C:32]4[NH:36][C:35](=[O:37])[O:34][N:33]=4)=[CH:22][CH:21]=3)=[C:15]([CH2:38][CH2:39][CH3:40])[N:14]=[C:13]2[CH3:41])=[CH:8][CH:7]=1)([CH3:4])[CH3:3].[Cl-].[Ca+2].[Cl-]>O>[CH:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:17](=[O:18])[C:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[C:32]4[NH:36][C:35](=[O:37])[O:34][N:33]=4)=[CH:22][CH:21]=3)=[C:15]([CH2:38][CH2:39][CH3:40])[N:14]=[C:13]2[CH3:41])=[CH:8][CH:7]=1)([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 5284359Calcium ChlorideHCID 1363531873-(4-Isopropoxyphenyl)-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3h)-one sodium salt

生成物 1

HCID 1358450103-(4-isopropoxyphenyl)-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one収率 74.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 3-(4-isopropoxyphenyl)-2-methyl-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one sodium salt (0.56 g) in water (2.0 mL) was added calcium chloride (0.056 g), and the mixture was stirred at room temperature for 1 hr. The resulting solid was collected by filtration to give the title compound (0.40 g, 71%) as a colorless solid.

後処理

  1. filtrationThe resulting solid was collected by filtration

出典と根拠

ORDレコード
ord-fd0d5d25735f492a8288a1d33a6b47f2
出典データセット
uspto-grants-2010_09
特許番号
US07803940B2

反応ノート

読み込み中…