N-benzyloxycarbonyl-S-(2-aminophenyl)cysteine → 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:22]([OH:24])=O)[CH2:13][S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH2:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C(C)=CC=CC=1>[CH2:1]([O:8][C:9]([NH:11][CH:12]1[C:22](=[O:24])[NH:21][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[S:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
17.8 g of N-benzyloxycarbonyl-S-(2-aminophenyl)cysteine was dissolved in 250 ml of xylene and the resulting solution was heated under reflux for 4 hours. After the solvent was distilled off under reduced pressure, ether was added to the residue. The precipitated crystals were separated to obtain 12.1 g of the desired compound, or 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one. Its melting point was 149°-151° C.
後処理
- temperaturethe resulting solution was heated