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Cystamine → 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cystamine | HCID 2915 | — |
| 反応物 | 5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one | HCID 3018360 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-[5-(3-Pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide | HCID 53790692 | — |
反応手順
Cystamine is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone by heating in ethanol to give 2-[5-(3-pyridylmethyl)-4-oxo-2-pyrimidylamino]ethyl disulphide which is reduced with dithiothreitol to give 2-(2-mercaptoethylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which is reacted with 5-dimethylaminomethyl-2-furylmethanol in cold aqueous hydrochloric acid to give 2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04539207 |
| 出典データセット | uspto-grants-1985_09 |
| ORD ID | ord-134cc2aa9a354edc9f55c3934bb430bd |
| 出典メモ | uspto-grants-1985_09 |