4-Methyl-2-(methylsulfanyl)-5-{[(methylsulfanyl)methoxy]methyl}pyrimidine → 5-[(Chloromethoxy)methyl]-4-methyl-2-(methylsulfanyl)pyrimidine

HRID 1719236ノート

反応式

HRID 1719236 の反応式
S(Cl)(Cl)(=O)=O.[CH3:6][S:7][C:8]1[N:13]=[C:12]([CH3:14])[C:11]([CH2:15][O:16][CH2:17][Cl:18])=[CH:10][N:9]=1.CSC1N=C(C)C(COCSC)=CN=1>ClCCl>[CH3:6][S:7][C:8]1[N:13]=[C:12]([CH3:14])[C:11]([CH2:15][O:16][CH2:17][Cl:18])=[CH:10][N:9]=1

参加物

4

反応物 2

HCID 202679394-Methyl-2-(methylsulfanyl)-5-{[(methylsulfanyl)methoxy]methyl}pyrimidineHCID 86740281HCID 86740281、化合物

生成物 1

HCID 202679405-[(Chloromethoxy)methyl]-4-methyl-2-(methylsulfanyl)pyrimidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-3 °C

実験手順

2-Methylthio-4-methyl-5-(chloromethyloxymethyl)pyrimidine Sulfuryl chloride (2.8 mmol) in dry dichloromethane (5 ml) was added dropwise over 15 minutes at -3° C. to a solution of 2-methylthio-4-methyl-5-(methylthiomethyloxy)methylpyrimidine (2.8 mmol) in dry dichloromethane (10 ml). The mixture was stirred at -3° C. for 10 minutes before the solution was evaporated at reduced pressure. The crude product (0.60 g, 98%) was used for alkylation in Example 10 without any further purification. 1H NMR (CDCl3): δ2.64 (4-CH3 and SCH3), 4.73 (CH2), 5.50 (CH2), 8.47 (H-6).

後処理

  1. customwas evaporated at reduced pressure
  2. customThe crude product (0.60 g, 98%) was used for alkylation in Example 10 without any further purification

出典と根拠

ORDレコード
ord-62c3c87e492147bb971788be64056faf
出典データセット
uspto-grants-1985_09
特許番号
US04539324

反応ノート

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