5-Bromo-2(1H)-pyrimidinone → 2(1H)-Pyrimidinone, 5-bromo-1-[(phenylmethoxy)methyl]-
反応式
Cl[CH2:2][O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Br:11][C:12]1[CH:13]=[N:14][C:15](=[O:18])[NH:16][CH:17]=1>>[CH2:4]([O:3][CH2:2][N:16]1[CH:17]=[C:12]([Br:11])[CH:13]=[N:14][C:15]1=[O:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
3
実験手順
was prepared as described in Example 3 from benzyl chloromethyl ether (see Preparation 1a and 1b) (4 mmol) and 5-bromopyrimidin-2-one by allowing the reaction to proceed for 20 hours at room temperature; yield 29% (0.34 g), m.p. 169° C. 1H NMR (CDCl3): δ4.65 (CH2Ph), 5.30 (CH2O), 7.18 (Ph), 7.78 and 8.40 (H-4, H-6, J 4 Hz). IR(KBr): 1670 cm-1 (CO).
後処理
- customwas prepared
- customthe reaction
出典と根拠
- ORDレコード
- ord-77f04ef5fb3049bc9193b687959dcd5d
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04539324
反応ノート
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