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Water → 2-(4-Pyridyl)propane-1,2-diol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Potassium Permanganate | HCID 516875 | — |
| 反応物 | Pyridine, 4-(1-methylethenyl) | HCID 529351 | — |
| 触媒 | Hydroquinone | HCID 785 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 2-(4-Pyridyl)propane-1,2-diol | HCID 20266430 | — |
反応手順
A solution of potassium permanganate (10.6 g) and magnesium sulphate (4.0 g) in water (250 cm3) was added at 0° to a mechanically stirred solution of 4-isopropenyl pyridine (14.8 g) in acetone (150 cm3) over 0.5 hours. After a further 0.5 hours at 0°, the mixture was warmed to room temperature over 1 hour, hydroquinone (0.01 g) was added and the mixture was filtered through "Avicel" (Trademark) to remove manganese dioxide. Solvents were removed in vacuo yielding a viscous oil which was chromatographed on silica ("Merck" 60.9385) eluting with methanol:chloroform, 1:19, to give 2-(4-pyridyl)propan-1,2-diol as an oil (6.0 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04542132 |
| 出典データセット | uspto-grants-1985_09 |
| ORD ID | ord-a63b00e2f17147718489bb298be276ac |
| 出典メモ | uspto-grants-1985_09 |