Hydrochloric Acid → 1-Chloroethyl 5-(2,4-difluorophenyl)salicylate
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:19]=[C:13]([C:14]([O:16][CH:17]=[CH2:18])=[O:15])[C:12]([OH:20])=[CH:11][CH:10]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:22].Cl>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:19]=[C:13]([C:14]([O:16][CH:17]([Cl:22])[CH3:18])=[O:15])[C:12]([OH:20])=[CH:11][CH:10]=1参加物
4
実験手順
To a mixture of vinyl 5-(2,4-difluorophenyl)salicylate (15 g) and 0.1 g dry PCl5, HCl gas is passed for about one hour at about 120°-125° C. Upon cooling, the crude product crystallizes and is collected by filtration. Recrystallization from methanol yields pure 1-chloroethyl 5-(2,4-difluorophenyl)salicylate.
後処理
- temperatureUpon cooling
- customthe crude product crystallizes
- filtrationis collected by filtration
- customRecrystallization from methanol
出典と根拠
- ORDレコード
- ord-b93616667151484ebf06b7783337ada1
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04542158
反応ノート
読み込み中…