Ammonia → 4,6-Bis(difluoromethoxy)pyrimidin-2-amine
反応式
[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6](S(C)(=O)=O)[N:5]=1.[NH3:19]>C(Cl)Cl>[F:1][CH:2]([F:18])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]=[C:6]([NH2:19])[N:5]=1参加物
4
実験手順
To a solution of 1.0 g of 4,6-bis(difluoromethoxy)-2-methylsulfonylpyrimidine in 20 ml of methylene chloride are added, with vigorous stirring, 5 ml of a 30% aqueous ammonia solution, in the course of which the reaction mixture warms up and is stirred for a further 2 hours. The solution is subsequently concentrated by evaporation and crystallised to thus obtain, in quantitative yield, (0.8 g) 4,6-bis(difluoromethoxy)-2-aminopyrimidine, m.p. 67°-69° C.
後処理
- concentrationThe solution is subsequently concentrated by evaporation
- customcrystallised
出典と根拠
- ORDレコード
- ord-f363504391a647df890474337d5414c1
- 出典データセット
- uspto-grants-1985_09
- 特許番号
- US04542216
反応ノート
読み込み中…