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Pyridine → Oleyloxyethyl phosphorylcholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | (2-Bromoethoxy)phosphonoyl dichloride | HCID 4684632 | — |
| 反応物 | Emulphor | HCID 5364713 | — |
| 反応物 | Chloroform acetone | HCID 15930782 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Oleyloxyethyl phosphorylcholine | HCID 13116658 | 9% |
反応手順
In benzene were dissolved 4.0 g of 2-[(Z)-9-octadecen-1-yl)oxyethanol and 4.6 g of 2-bromoethyl phosphorodichloridate, and following dropwise addition of 1.5 g of pyridine under ice-cooling, the mixture was stirred at room temperature. The reaction mixture was treated by the procedure of Production Example 1 including hydrolysis, quaternization, purification by silica gel column chromatography and recrystallization from chloroform-acetone to give 0.52 g (9%) of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04542219 |
| 出典データセット | uspto-grants-1985_09 |
| ORD ID | ord-686d7471b1af47a4967c586248a8bbef |
| 出典メモ | uspto-grants-1985_09 |