(RS)-Naproxen methyl ester → 2-(6-Methoxy-2-naphthyl)propionic acid

HRID 1719809

反応式

HRID 1719809 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:18])[C:14]([O:16]C)=[O:15])[CH:7]=[CH:6]2.CO.[OH-].[K+].O>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:18])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2

参加物

4

反応物 2

HCID 529084(RS)-Naproxen methyl esterHCID 86591755KOH MeOH Water

生成物 1

HCID 13022-(6-Methoxy-2-naphthyl)propionic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The crude methyl 2-(6-methoxy-2-naphthyl)propionate is hydrolyzed with methanol/potassium hydroxide/water until TLC indicates no remaining ester. Then the reaction mixture is poured into water and extracted with methylene chloride and acidified with hydrochloric acid. The mixture is filtered and the organic and aqueous layers are separated. The aqueous layer then is acidified and filtered to yield 13.5 g of 2-(6-methoxy-2-naphthyl)propionic acid (melting point: 153°-155° C.).

後処理

  1. extractionextracted with methylene chloride
  2. filtrationThe mixture is filtered
  3. customthe organic and aqueous layers are separated
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-2f3d07daeb9a4c1d86d82bc027c3e674
出典データセット
uspto-grants-1985_09
特許番号
US04542237

関連ノート

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