Dimethylformamide → Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate

HRID 1719954

反応式

HRID 1719954 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.CO[CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25].CN(C)C=O>O>[CH3:27][O:26][C:24](=[O:25])[C:23](=[CH:22][NH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:28]([O:30][CH3:31])=[O:29]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 90770Dimethyl methoxymethylenemalonateHCID 130604624-Amino-6-(2-ethylbutyramido)quinazoline

生成物 1

HCID 13060503Dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate収率 56.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-amino-6-(2-ethylbutyramido)-quinazoline (5.58 g), dimethyl methoxymethylenepropanedioate (5.62 g) and N,N-dimethylformamide (22 ml) was stirred at 100° C. for 1.5 hours. After cooling to ambient temperature, water (90 ml) was added to the reaction mixture. The resulting solid was separated by filtration, washed with water and dried to give dimethyl[[6-(2-ethylbutyramido)-4-quinazolinylamino]methylene]propanedioate (4.85 g).

後処理

  1. temperatureAfter cooling to ambient temperature
  2. customThe resulting solid was separated by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-40395b298bb54901846d5292396fb08b
出典データセット
uspto-grants-1985_09
特許番号
US04543356

関連ノート

読み込み中…