Hydrochloric Acid → Ethyl indoline-2-carboxylate

HRID 1720001ノート

反応式

HRID 1720001 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([OH:12])=[O:11].[ClH:13].[CH2:14](O)[CH3:15]>>[ClH:13].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([O:12][CH2:14][CH3:15])=[O:11]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 2733920Indoline-2-carboxylic acid, (S)-

生成物 1

HCID 22822759Ethyl indoline-2-carboxylate

実験手順

A suspension of (S)-indoline-2-carboxylic acid (6.02 g., 36.9 mmol.) in ethanol (70 ml.) at 0° was saturated with hydrochloric acid and allowed to warm to room temperature. After 3 hours at room temperature, the resulting clear, red solution was purged with nitrogen and diluted with ethyl ether (200 ml.). The crystallized product was collected, washed with ethyl ether and dried in vacuo to give 6.43 g. of the title compound as white needles, m.p. 168°-169°; α!D =-70.7° (c=0.68, chloroform). TLC (ethyl acetate-hexane, 1:1) Rf =0.63 (as free base).

後処理

  1. customthe resulting clear, red solution was purged with nitrogen
  2. additiondiluted with ethyl ether (200 ml.)
  3. customThe crystallized product was collected
  4. washwashed with ethyl ether
  5. customdried in vacuo
  6. customto give 6.43 g

出典と根拠

ORDレコード
ord-2341f1275cda4573a992c40ec7d37def
出典データセット
uspto-grants-1996_04
特許番号
US05504080

反応ノート

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