Nitromethane → 5-Benzyl-3-(2-nitroethenyl)indole

HRID 1720066ノート

反応式

HRID 1720066 の反応式
[CH2:1]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[CH:17]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+].[N+:24]([CH3:27])([O-:26])=[O:25]>>[CH2:1]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[CH:17]=[CH:27][N+:24]([O-:26])=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 6375NitromethaneHCID 517165Ammonium AcetateHCID 224199495-Benzyl-3-formylindole

生成物 1

HCID 544807005-Benzyl-3-(2-nitroethenyl)indole収率 34%

実験手順

The aidehyde 5-benzyl-3-formylindole (0.15 g, 0.6 mmol), nitromethane (0.9 ml) and ammonium acetate (0.05 g, 0.7 mmol) were heated gently under reflux for 0.5 h. On cooling, dark ruby-red crystals slowly separated. Crystallization from methanol gave 0.06 g (34%) of 5-benzyl-3-(2-nitroethenyl)indole as orange crystals.

後処理

  1. temperatureunder reflux for 0.5 h
  2. temperatureOn cooling
  3. customdark ruby-red crystals slowly separated
  4. customCrystallization from methanol

出典と根拠

ORDレコード
ord-2d33d545fdde434f935645275ad74aa6
出典データセット
uspto-grants-1996_04
特許番号
US05504101

反応ノート

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