Hydrochloric Acid → HCID 18655292、化合物
反応式
[ClH:1].[CH2:2]([NH:10][C:11](=[O:25])[C@H:12]([C@H:21]([CH2:23][CH3:24])[CH3:22])[NH:13]C(OC(C)(C)C)=O)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CCCCCC>CCOC(C)=O>[ClH:1].[CH2:2]([NH:10][C:11](=[O:25])[C@H:12]([C@H:21]([CH2:23][CH3:24])[CH3:22])[NH2:13])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
Hydrogen chloride gas was bubbled into a solution of N-t-butoxycarbonyl-L-isoleucine-phenethylamide (3.1 g, 9.3 mmol) in EtOAc (200 mL) at -20° C. in a dry ice-acetone bath until TLC (EtOAc: hexane, 1:3) indicated complete loss of starting material. The solution was concentrated to dryness to give 2.5 g (100%) of the title compound, which was used without further purification.
後処理
- concentrationThe solution was concentrated to dryness
出典と根拠
- ORDレコード
- ord-6d7d47a79c7d4c3ea39825bfc0255958
- 出典データセット
- uspto-grants-1996_04
- 特許番号
- US05504115
反応ノート
読み込み中…