Water → omega-Cyclohexyldodecanoic acid

HRID 1720805

反応式

HRID 1720805 の反応式
[OH2:1].[CH:2]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>S(=O)(=O)(O)O.CC(C)=O>[CH:2]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:1])=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

5

反応物 2

HCID 962WaterHCID 1487778512-Cyclohexyldodecanol

生成物 1

HCID 193525omega-Cyclohexyldodecanoic acid収率 58.7%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 1118Sulfuric Acid溶媒

実験手順

CrO3 (VI) (3.204 g, 32.04 mM) was dissolved in sulfuric acid (2.76 ml), followed by stirring for a time, and then water (4.8 ml) was added to yield a solution. This solution was added drop by drop to a solution of 12-cyclohexyldodecanol (5.36 g, 20 mM) in acetone (300 ml) under ice cooling conditions, followed by stirring for 1 hour. To the mixture, iso-prapanol (about 2 ml) was added and then concentrated to dryness under reduced pressure. To the resulting residue, water (50 ml) and chloroform (50 ml) were added, followed by vigorous stirring, after which the chloroform layer was separated. The chloroform layer was dryed over anhydrous sodium sulfate, purified by silica gel colum (50 g) (methanol-chloroform (1:49)) to yield the title compound (5.3 g, yield 58.7%) as a colorless powder.

後処理

  1. customto yield a solution
  2. stirringby stirring for 1 hour
  3. additionTo the mixture, iso-prapanol (about 2 ml) was added
  4. concentrationconcentrated to dryness under reduced pressure
  5. additionTo the resulting residue, water (50 ml) and chloroform (50 ml) were added
  6. customafter which the chloroform layer was separated
  7. custompurified by silica gel colum (50 g) (methanol-chloroform (1:49))

出典と根拠

ORDレコード
ord-c215d465787f42319d335885df261e62
出典データセット
uspto-grants-1996_04
特許番号
US05506267

関連ノート

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