Hydrochloric Acid → (3aR,7S,7aR)-7-chloro-4,4-diphenyl-perhydroisoindole hydrochloride
反応式
Cl.C(OC([N:9]1[CH2:17][C@@H:16]2[C@@H:11]([C@@H:12]([Cl:30])[CH2:13][CH2:14][C:15]2([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:30].[Cl:30][C@@H:12]1[C@@H:11]2[C@@H:16]([CH2:17][NH:9][CH2:10]2)[C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:14][CH2:13]1参加物
4
実験手順
10 cm3 of a 6.3N solution of hydrochloric acid in dioxane are added to a solution of 1.03 g of (3aR, 7S, 7aR)-2-tert-butyloxycarbonyl-7-chloro-4,4-diphenylperhydroisoindole in 5 cm3 of dioxane. The reaction mixture is stirred at room temperature for 2 hours and then concentrated to dryness under reduced pressure (2.7 kPa). 0.84 g of (3aR, 7S, 7aR)-7-chloro-4,4-diphenylperhydroisoindole hydrochloride is obtained in the form of a solid which is used in the crude state in the following test.