1(2H)-Isoquinolinone → 1,2,3,4-Tetrahydro-1-naphthalenecarboxamide

HRID 1721444

反応式

HRID 1721444 の反応式
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][NH:2]1.[CH3:12][CH2:13]C(N)CCCCC>>[CH:10]1([C:1]([NH2:2])=[O:11])[C:5]2[C:6](=[CH:12][CH:13]=[CH:3][CH:4]=2)[CH2:7][CH2:8][CH2:9]1

参加物

3

反応物 2

HCID 102841(2H)-IsoquinolinoneHCID 5473623-Octanamine2 回

生成物 1

HCID 2720421,2,3,4-Tetrahydro-1-naphthalenecarboxamide

実験手順

A preferred process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one is that in which L is chloro and the 1-azabicyclo 2.2.2!oct-3-ylamine is (S)-1-azabicyclo 2.2.2!oct-3-ylamine and is reacted with the compound of Formula 5 to give N-(1-azabicyclo 2.2.2!oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide; and preferably wherein the N-(1-azabicyclo 2.2.2!oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide is then reduced as N-(1-azabicyclo 2.2.2!oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1S-ylcarboxamide.

後処理

  1. customA preferred process for preparing 2-(1-azabicyclo

出典と根拠

ORDレコード
ord-37cc6dfb20b94cda976dde7e2b264d52
出典データセット
uspto-grants-1996_04
特許番号
US05510486

関連ノート

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