Hydrochloric Acid → HCID 19972019、化合物
反応式
[ClH:1].C1(C(C2C=CC=CC=2)=[N:9][CH:10]([P:18]([CH:23]([N:31]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)C=CC=CC=1>CCOCC>[ClH:1].[NH2:31][CH:23]([P:18]([CH:10]([NH2:9])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:22])[O:19][CH2:20][CH3:21])[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1参加物
4
実験手順
Approximately 10% strength aqueous hydrochloric acid (30 ml) is added to a solution of the bis-alkylated phosphinate 5 (1161 mg; 1.76 mmol) in ether (30 ml) at room temperature with stirring. After 24 hours the organic phase is separated off and the aqueous phase is extracted with ethyl acetate (20 ml). The phosphinate hydrochloride 10 (690 mg, 97% of theory) is obtained after freeze-drying.