Water → (1R,2E)-2-hydroxyimino-1,2-diphenylethanol;trans-(1R,2R)-cyclohexane-1,2-diamine

HRID 1721505ノート

反応式

HRID 1721505 の反応式
[C@@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[NH2:7].O.[OH:10][CH:11]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:12](=[N:19][OH:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1C=CC=CC=1>[C@@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]1[NH2:7].[OH:10][C@H:11]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)/[C:12](=[N:19]/[OH:20])/[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 9924(+-)-Benzoin oximeHCID 438061,2-Diaminocyclohexane, trans-

生成物 1

HCID 88417869(1R,2E)-2-hydroxyimino-1,2-diphenylethanol;trans-(1R,2R)-cyclohexane-1,2-diamine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

2.00 g (17.5 mmol) of (1R,2R)-(-)-1,2-cyclohexanediamine of α!D20 =-36.7° (c 4.14, H2O) and 4.00 g (17.6 mmol) of dl-1-hydroxy-2-hydroxyimino-1,2-diphenylethane were added to 10 ml of benzene and then heated and stirred, and the solution was cooled to room temperature. Afterward, the precipitated crystals were collected by filtration and then recrystallized from 30 ml of benzene twice to obtain 2.30 g of (1R,2R)-(-)-1,2-cyclohexanediamine·(R)-(-)-(E)-1-hydroxy-2-hydroxyimino-1,2-diphenylethane. Physical properties of the product are as follows.

後処理

  1. temperatureheated
  2. filtrationAfterward, the precipitated crystals were collected by filtration
  3. customrecrystallized from 30 ml of benzene twice

出典と根拠

ORDレコード
ord-7ddafd4ef86d43d394d657817c8bf3e6
出典データセット
uspto-grants-1996_04
特許番号
US05510520

反応ノート

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