1-Chloro-2,4,6-trifluorobenzene → 1,3,5-Trifluorobenzene

HRID 1721515

反応式

HRID 1721515 の反応式
Cl[C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[F:10]>[Cu].[Zn].S([O-])([O-])(=O)=O.[Cu+2].[Zn].O>[F:8][C:7]1[CH:2]=[C:3]([F:10])[CH:4]=[C:5]([F:9])[CH:6]=1

参加物

6

反応物 1

HCID 27366621-Chloro-2,4,6-trifluorobenzene

生成物 1

HCID 97451,3,5-Trifluorobenzene収率 42%

試薬・触媒・溶媒 4

HCID 23994Zinc触媒HCID 24462Copper Sulfate触媒HCID 10290809Zinc copper couple触媒HCID 962Water溶媒

反応条件

温度
330 °C

実験手順

An autoclave was charged with 6.68 g of 2-chloro-1,3,5-trifluorobenzene, 0.5 g of water and 7.5 g of 3-5% zinc-copper couple (prepared by adding an aqueous solution of copper sulfate to an aqueous dispersion of zinc powder (copper/zinc weight ratio of 3 to 5%), allowing the mixture to stand, filtering out the solid component under reduced pressure, and washing, drying and pulverizing the solid component in a mortar), and the content was heated at 330° C. with high speed stirring for 32 hours. After the reaction, the content was distilled off, and a fraction distilled off at 74° to 77° C. was dried over sodium sulfate to obtain 1,3,5-trifluorobenzene in an amount of 2.19 g (yield 42%).

後処理

  1. customprepared
  2. filtrationfiltering out the solid component under reduced pressure
  3. washwashing
  4. customdrying
  5. customAfter the reaction
  6. distillationthe content was distilled off
  7. distillationa fraction distilled off at 74° to 77° C.
  8. dry with materialwas dried over sodium sulfate

出典と根拠

ORDレコード
ord-7ab27560425f41dbbe58ca1101c9c981
出典データセット
uspto-grants-1996_04
特許番号
US05510533

関連ノート

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