Hydrochloric Acid → 1,1'-Binaphthalene, 2,2'-dimethyl-

HRID 1721537

反応式

HRID 1721537 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[Mg]Br.Br[C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]=1[CH3:25].P.C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(COC2C=CC3C(=CC=CC=3)C=2C2C3C(=CC=CC=3)C=CC=2OCP(C2C=CC=CC=2)C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.Cl>C1(C)C=CC=CC=1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]=1[CH3:25]

参加物

10

反応物 6

HCID 313Hydrochloric AcidHCID 24404Phosphine2 回HCID 757541-Bromo-2-methylnaphthaleneHCID 821241,4-Bis(diphenylphosphino)butaneHCID 118285682,2'-Bis(diphenylphosphinomethoxy)-1,1'-binaphthylHCID 178422613HCID 178422613、化合物

生成物 1

HCID 1417481,1'-Binaphthalene, 2,2'-dimethyl-

試薬・触媒・溶媒 3

HCID 167845palladium(II) acetate触媒HCID 962Water溶媒HCID 1140Toluene溶媒2 回

反応条件

温度
80 °C

実験手順

2-Methyl-1-naphthylmagnesium bromide prepared according to Example 1 in toluene is added in the absence of air and moisture to a suspension, heated to 70° to 80° C., of 31.0 g (0.14 mol) of 1-bromo-2-methylnaphthalene, 0.0014 mol of the phosphine of the formula (I) 1,4-bis(diphenylphosphino)butane; 2,2'-bis(diphenylphosphinomethoxy)-1,1'-binaphthyl! or 0.0028 mol of the phosphine of the formula (II) (triphenylphosphine) and 0.31 g (0.0014 mol) of palladium(II) acetate in 50 ml of toluene. The mixture is then heated at 80° C. for another hour, cooled to 25° C., and 100 ml of water and 50 ml of 2N hydrochloric acid are added in succession to the reaction mixture. The phases are separated, the aqueous phase is extracted with 50 ml of toluene, and the combined organic phases are concentrated in vacuo. Distillation of the oily, brown residue in a high vacuum gives a pale yellow oil having a boiling point of 175° to 180° C./0.1 to 0.2 mbar. The yields can be found in Table 1 below.

後処理

  1. additionis added in the absence of air and moisture to a suspension
  2. temperaturecooled to 25° C.
  3. customThe phases are separated
  4. extractionthe aqueous phase is extracted with 50 ml of toluene
  5. concentrationthe combined organic phases are concentrated in vacuo
  6. distillationDistillation of the oily, brown residue in a high vacuum
  7. customgives a pale yellow oil
  8. customThe yields can

出典と根拠

ORDレコード
ord-4366f3247c8f4e719e3b89237ebb09a7
出典データセット
uspto-grants-1996_04
特許番号
US05510554

関連ノート

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