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2-Chlorobenzaldehyde → 5-(2-Chlorophenyl)-6-methoxycarbonyl-1,3-dimethyl-7-[2-(2,4,5-trimethylimidazol-1-yl)ethoxymethyl]-1,2,3,4,5,8-hexahydro-2,4-dioxopyrido[2,3-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorobenzaldehyde | HCID 6996 | — |
| 反応物 | 6-Amino-1,3-dimethyluracil | HCID 81152 | — |
| 反応物 | Methyl 4-[2-(2,4,5-trimethylimidazol-1-yl)ethoxy]3-oxobutanoate | HCID 20070375 | — |
| 生成物 | 5-(2-Chlorophenyl)-6-methoxycarbonyl-1,3-dimethyl-7-[2-(2,4,5-trimethylimidazol-1-yl)ethoxymethyl]-1,2,3,4,5,8-hexahydro-2,4-dioxopyrido[2,3-d]pyrimidine | HCID 20070365 | 4% |
反応手順
The title compound (210 mg) was prepared from 2-chlorobenzaldehyde (1.4 g), 6-amino-1,3-dimethyl-2,4-dioxopyrimidine (1.55 g) and methyl 4-[2-(2,4,5-trimethylimidazol-1-yl)ethoxy]3-oxobutanoate (2.68 g) by the method of Exmaple 1. M.p. 226°-228° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04853392 |
| 出典データセット | uspto-grants-1989_08 |
| ORD ID | ord-426a2e56bb3840f8b86ba96f80642646 |
| 出典メモ | uspto-grants-1989_08 |