4-Chlorobenzaldehyde → 2-(4-Chlorophenyl)-3-(1,2,4-triazol-1-yl)chroman-4-one

HRID 1721918

反応式

HRID 1721918 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.O[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17](=[O:24])[CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1>CN(C)C=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]2[CH:18]([N:19]3[CH:23]=[N:22][CH:21]=[N:20]3)[C:17](=[O:24])[C:12]3[CH:11]=[CH:16][CH:15]=[CH:14][C:13]=3[O:7]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 77264-ChlorobenzaldehydeHCID 159063601-(2-Hydroxyphenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one

生成物 1

HCID 200301272-(4-Chlorophenyl)-3-(1,2,4-triazol-1-yl)chroman-4-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

4-Chlorobenzaldehyde (1.18 g) was added to 2'-hydroxy-2-(1,2,4-triazol-1-yl)acetophenone, obtained in Example 6 (1.7 g), in dry dimethylformamide (20 ml). The mixture was stirred at 90° C. for 24 hours. It was then poured into ice/water, extracted with dichloromethane and the extract dried and evaporated. The residual oil was triturated with diisopropyl ether to give 2-(4-chlorophenyl)-2,3-dihydro-3-(1,2,4-triazol-1-yl)-benzopyran-4-one, m.p. 140°-1° C. (Compound 15).

後処理

  1. extractionextracted with dichloromethane
  2. customthe extract dried
  3. customevaporated
  4. customThe residual oil was triturated with diisopropyl ether

出典と根拠

ORDレコード
ord-e598e345f05f428785512b3e69d6a4ab
出典データセット
uspto-grants-1989_08
特許番号
US04853400

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