alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol → HCID 14622775、化合物

HRID 1721928ノート

反応式

HRID 1721928 の反応式
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:26])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:13]([Cl:24])[C:12]=2[Cl:25])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:24][C:13]1[C:12]([Cl:25])=[C:11]([C:10]([C:9]2[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=2)=[O:26])[CH:16]=[CH:15][C:14]=1[O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

参加物

4

反応物 1

HCID 20030167alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol

生成物 1

HCID 14622775HCID 14622775、化合物収率 91.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

770 mg of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol and 1.66 g of manganese dioxide are suspended in 30 ml of methylene chloride, and the suspension is stirred at room temperature for 24 hours. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is triturated with a mixture of isopropyl ether and hexane to give 703 mg of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate as crystals.

後処理

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. customto remove solvent
  4. customThe residue is triturated with a mixture of isopropyl ether and hexane

出典と根拠

ORDレコード
ord-23b98d0e30544857bf6ad14b79aa5454
出典データセット
uspto-grants-1989_08
特許番号
US04853404

反応ノート

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