HCID 15631682、化合物 → HCID 14622782、化合物

HRID 1721934ノート

反応式

HRID 1721934 の反応式
O.O.O.[Br:4]([O-])=O.[Na+].[Cl:8][C:9]1[C:21]([Cl:22])=[C:20]([C:23]([C:25]2[N:29]([CH2:30][CH3:31])[N:28]=[CH:27][CH:26]=2)=[O:24])[CH:19]=[CH:18][C:10]=1[O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>O>[Cl:8][C:9]1[C:21]([Cl:22])=[C:20]([C:23]([C:25]2[N:29]([CH2:30][CH3:31])[N:28]=[CH:27][C:26]=2[Br:4])=[O:24])[CH:19]=[CH:18][C:10]=1[O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

参加物

4

反応物 2

HCID 15631682HCID 15631682、化合物HCID 86743274HCID 86743274、化合物

生成物 1

HCID 14622782HCID 14622782、化合物収率 88.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.88 g of sodium bromite trihydrate in 5 ml of water is added dropwise at room temperature to a solution of 1.85 g of ethyl [2,3-dichloro-4-(1-ethyl-5-pyrazolylcarbonyl)phenoxy]acetate and the mixture is stirred at room temperature for 15 hours. The reaction mixture is evaporated to remove solvent and the residue is dissolved in 20 ml of water. The aqueous solution is made alkaline with a saturated sodium bicarbonate solution and extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. The residue is crystallized with a mixture of isopropyl ether and hexane to give 1.98 g of ethyl [2,3-dichloro-4-(4-bromo-1-ethyl-5-pyrazolylcarbonyl)phenoxy]acetate.

後処理

  1. customThe reaction mixture is evaporated
  2. customto remove solvent
  3. dissolutionthe residue is dissolved in 20 ml of water
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with water
  6. customdried
  7. customevaporated
  8. customto remove solvent
  9. customThe residue is crystallized with a mixture of isopropyl ether and hexane

出典と根拠

ORDレコード
ord-6892f7e8dc684123898c8e161250dd5f
出典データセット
uspto-grants-1989_08
特許番号
US04853404

反応ノート

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