alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol → HCID 14622785、化合物

HRID 1721936ノート

反応式

HRID 1721936 の反応式
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:21])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Cl:19])[C:12]=2[Cl:20])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:20][C:12]1[C:13]([Cl:19])=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:10]([C:9]1[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=1)=[O:21]

参加物

4

反応物 1

HCID 14622784alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol

生成物 1

HCID 14622785HCID 14622785、化合物収率 90%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

2.72 g of manganese dioxide are added to a solution of 1.04 g of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxybenzylalcohol in methylene chloride and the mixture is stirred at room temperature for 27 hours. The reaction mixture is filtered and the filtrate is condensed to an oily residue, which is then crystallized from isopropyl ether to give 0.93 g of (2,3-dichloro-4-methoxyphenyl)(1-ethoxymethyl-5-pyrazolyl)methanone.

後処理

  1. filtrationThe reaction mixture is filtered
  2. customcondensed to an oily residue, which
  3. customis then crystallized from isopropyl ether

出典と根拠

ORDレコード
ord-4c141264c8fb4744bc6d536ffdaf317e
出典データセット
uspto-grants-1989_08
特許番号
US04853404

反応ノート

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