(+-)-3,4-Dimethoxyamphetamine → 3-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol

HRID 1721988

反応式

HRID 1721988 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:15]1[O:17][CH:16]1[CH2:18][OH:19]>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:17])[CH2:18][OH:19])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

参加物

4

反応物 2

HCID 8423(+-)-3,4-DimethoxyamphetamineHCID 11164Glycidol

生成物 1

HCID 537726823-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

反応条件

温度
50 °C

実験手順

A solution of 3-(3,4-dimethoxyphenyl)-2-propylamine (20.0 g, 0.10 m) in isopropanol (20 ml) is heated to 50° C. while a solution of glycidol (5.0 g, 0.067 m) in isopropanol (5 ml) is added over 15 minutes. The mixture is stirred at 50° C. for 0.5 hours and then at 70° C. for 16 hours. The solvent is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 10% MeOH-CHCl3 saturated with NH3 to yield (I) weighing 14.37 g (80%).

後処理

  1. additionis added over 15 minutes
  2. waitat 70° C. for 16 hours
  3. concentrationThe solvent is concentrated under reduced pressure
  4. customthe residue is chromatographed on silica gel
  5. washeluting with 10% MeOH-CHCl3 saturated with NH3

出典と根拠

ORDレコード
ord-18b420efafa646a69ce9fe47367152b1
出典データセット
uspto-grants-1989_08
特許番号
US04853383

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