Benzaldehyde → 3-(3,4-Dimethoxyphenyl-2-propyl]-5-hydroxymethyl-2-phenyloxazolidine

HRID 1721989

反応式

HRID 1721989 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:19])[CH2:17][OH:18])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(O)(=O)C1C=CC=CC=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([N:14]2[CH2:15][CH:16]([CH2:17][OH:18])[O:19][CH:20]2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 243Benzoic AcidHCID 537726823-[3-(3,4-Dimethoxyphenyl)-2-propylamino]1,2-propanediol

生成物 1

HCID 147206783-(3,4-Dimethoxyphenyl-2-propyl]-5-hydroxymethyl-2-phenyloxazolidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 3-[3-(3,4-dimethoxyphenyl)-2-propylamino]-1,2-propanediol (14.3 g, 0.053 m), benzaldehyde (12.7 g, 0.12 m) and benzoic acid (0.3 g) in toluene (45 ml) is refluxed for 3 hours, collecting the water formed in a Dean-Stark trap. After washing with saturated NaHCO3 solution and with H2O (2x), the solvent is distilled under reduced pressure. Excess benzaldehyde is distilled at 100° C. at 0.1 mm. The residue, (II) (16.88 g, 89%) is used without further purification in the next step.

後処理

  1. temperatureis refluxed for 3 hours
  2. customcollecting the water
  3. customformed in a Dean-Stark trap
  4. washAfter washing with saturated NaHCO3 solution and with H2O (2x)
  5. distillationthe solvent is distilled under reduced pressure
  6. distillationExcess benzaldehyde is distilled at 100° C. at 0.1 mm
  7. customThe residue, (II) (16.88 g, 89%) is used without further purification in the next step

出典と根拠

ORDレコード
ord-6401a07160af4a8faf8f09b7e173225f
出典データセット
uspto-grants-1989_08
特許番号
US04853383

関連ノート

読み込み中…