1-Benzyl-3-acetamidopyrrolidine → 3-Acetamidopyrrolidine

HRID 1722085ノート

反応式

HRID 1722085 の反応式
[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)(=[O:3])[CH3:2]>C(O)C.O.[C].[Pd]>[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][NH:7][CH2:6]1)(=[O:3])[CH3:2]

参加物

5

反応物 1

HCID 41983391-Benzyl-3-acetamidopyrrolidine

生成物 1

HCID 5227153-Acetamidopyrrolidine収率 97.9%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of the above 3-acetylamino-1-benzylpyrrolidine (4.0 g) in ethanol (30 ml) was added 10% palladium-carbon (0.8 g) in water (1 ml). The mixture was shaken at room temperature for 22 hours under hydrogen pressure of 55 p.s.i. using Parr hydrogenator. The catalyst was filtered off and the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform and dried over anhydrous magnesium sulfate, followed by distilling off the solvent to give 3-acetylaminopyrrolidine (2.3 g) as oil.

後処理

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationby distilling off the solvent

出典と根拠

ORDレコード
ord-004e964c05094558bb944e448effad59
出典データセット
uspto-grants-1989_08
特許番号
US04853469

反応ノート

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