Potassium Hydroxide → HCID 23049308、化合物

HRID 1722219ノート

反応式

HRID 1722219 の反応式
[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CO.O>[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 10656958HCID 10656958、化合物

生成物 1

HCID 23049308HCID 23049308、化合物収率 91.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

反応条件

温度
50 °C

実験手順

To a solution of ethyl 7-phenylhept-2E-en-6-ynoate (2.5 g) in methanol was added KOH (2.6 g) in water (6 ml). The mixture was stirred at 50° C. under a nitrogen atmosphere for 40 minutes, cooled, diluted with water (20 ml) and washed with ether (15 ml). The aqueous layer was acidified with 10% HCl and extracted with ether. The ether extracts were combined and dried over MgSO4, and the solvent was distilled off (adding dry benzene (4 ml) to form azeotrope with traces of water) to give 7-phenylhept-2E-en-6-ynoic acid (2 g) as a colourless oily solid.

後処理

  1. temperaturecooled
  2. washwashed with ether (15 ml)
  3. extractionextracted with ether
  4. dry with materialdried over MgSO4
  5. distillationthe solvent was distilled off
  6. addition(adding dry benzene (4 ml) to form azeotrope with traces of water)

出典と根拠

ORDレコード
ord-025e0a7adfa04361ba9862272893340c
出典データセット
uspto-grants-1989_08
特許番号
US04855086

反応ノート

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