Potassium Hydroxide → HCID 14180954、化合物
反応式
[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:16]CC)=[O:15])=[CH:9][CH:8]=1)(=[O:4])=[O:3].[OH-].[K+]>C(O)C.O>[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)(=[O:4])=[O:3]参加物
5
実験手順
A solution of ethyl 4-[[(methylsulphonyl)amino]methyl]benzeneacetate (3.1 g) and 1M KOH (22 ml) in ethanol (50 ml) was stirred at room temperature for 3 h and evaporated in vacuo to leave an off-white solid. This solid was dissolved in water (50 ml) and washed with EA (2×50 ml). The organic extract was discarded and the aqueous layer was acidified (pH1) with 5M hydrochloric acid (about 10 ml) to precipitate the title compound (2.54 g) as a white solid m.p. 167°-169°.
後処理
- customevaporated in vacuo
- customto leave an off-white solid
- washwashed with EA (2×50 ml)
- extractionThe organic extract
- customto precipitate the title compound (2.54 g) as a white solid m.p. 167°-169°
出典と根拠
- ORDレコード
- ord-9b4030efb73046d4954e2a145c2a3cae
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04855314
反応ノート
読み込み中…