tert-Butyl bromoacetate → HCID 20028930、化合物

HRID 1722562ノート

反応式

HRID 1722562 の反応式
[Cl:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.Br[CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>C(Cl)Cl.S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC>[C:12]([O:11][C:9]([CH2:8][N:3]1[CH:4]=[CH:5][N:6]=[C:2]1[Cl:1])=[O:10])([CH3:15])([CH3:14])[CH3:13]

参加物

5

反応物 2

HCID 79177tert-Butyl bromoacetateHCID 27733282-chloro-1H-imidazole

生成物 1

HCID 20028930HCID 20028930、化合物

試薬・触媒・溶媒 2

HCID 94433Tetrabutylammonium hydrogen sulfate触媒HCID 6344Dichloromethane溶媒

実験手順

The starting material was prepared by reaction of 2-chloroimidazole with t-butyl bromoacetate in CH2Cl2 /aqueous sodium hydroxide in presence of tetra-n-butyl ammonium hydrogen sulphate to give 1-t-butoxycarbonylmethyl-2-chloroimidazole. Reaction of this compound with trimlethyloxonium tetrafluoroborate in CH2Cl2 gave 1-t-butoxycarbonylmethyl-2-chloro-3-methylimidazolium tetrafluoroborate; n.m.r. in d6DMSO:-1.5(s, 9H); 3.9(s, 3H); 5.17(s, 2H); 7.81(d, 1H): 7.85(d, 1H).

出典と根拠

ORDレコード
ord-7ab58564d57e486eab25deffd3ea64bb
出典データセット
uspto-grants-1989_08
特許番号
US04855420

反応ノート

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