Toluene → Benzoic acid, 4-(acetylamino)-2-hydroxy-3-(2-propenyl)-, methyl ester

反応式

C([O:4][C:5]1[CH:14]=[C:13]([NH:15][C:16](=[O:18])[CH3:17])[CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])C=C.[C:19]1(C)[CH:24]=CC=C[CH:20]=1>>[CH2:24]([C:14]1[C:13]([NH:15][C:16](=[O:18])[CH3:17])=[CH:12][CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:5]=1[OH:4])[CH:19]=[CH2:20]

参加物

反応物 2

HCID 1140Toluene

HCID 10586690HCID 10586690、化合物

生成物 1

HCID 10800613Benzoic acid, 4-(acetylamino)-2-hydroxy-3-(2-propenyl)-, methyl ester

実験手順

A solution of 5 g (20.1 mmol) of the allyl ether from Example 19 in 20 ml of toluene is heated at 200° C. in a sealed tube for 24 hours. After cooling to room temperature a precipitate begins forming and the reaction mixture is cooled further to 0° C. The precipitate is filtered off and allowed to air dry, giving methyl 3-allyl-4-acetylaminosalicylate which can be used directly in the next step.

後処理

custombegins forming
temperaturethe reaction mixture is cooled further to 0° C
filtrationThe precipitate is filtered off
customto air dry

出典と根拠

ORDレコード: ord-a4176f6ab4a348628abbf541c96a8b25
出典データセット: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04857517

反応ノート

読み込み中…

参加物