Water → 2-(Trimethylstannyl)furan

HRID 1722756ノート

反応式

HRID 1722756 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.C([Li])CCC.[CH3:11][Sn:12](Cl)([CH3:14])[CH3:13].O>CCOCC>[CH3:11][Sn:12]([CH3:14])([CH3:13])[C:2]1[O:1][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 8029FuranHCID 14016Trimethyltin chlorideHCID 178418339Butyllithium

生成物 1

HCID 98133762-(Trimethylstannyl)furan収率 96.3%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
-30 °C

実験手順

To a solution of 6.8 g furan in 100 ml dry ether at 0° C. under nitrogen was added 10.5 ml 9.5M n-butyllithium. The reaction mixture was heated at reflux for 15 min., then cooled to -30° C. and 19.9 g trimethyltin chloride was added. The reaction mixture was allowed to warm to room temperature and then poured into water. The ether layer was separated, washed with water and passed through an alumina column, eluting with hexane. Removal of the solvent provided 22.2 g (96%) 2-(trimethylstannyl)furan as a pale-yellow liquid.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 15 min.
  3. temperatureto warm to room temperature
  4. customThe ether layer was separated
  5. washwashed with water
  6. washeluting with hexane
  7. customRemoval of the solvent

出典と根拠

ORDレコード
ord-aa2fe65b8d0549c1bb485d131c39a3f1
出典データセット
uspto-grants-1989_08
特許番号
US04857539

反応ノート

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