Diketene → N-(2-morpholin-4-ylethyl)-3-oxobutanamide

HRID 1722788

反応式

HRID 1722788 の反応式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C(OCC)C>[O:13]1[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:11][CH2:12]1

参加物

4

反応物 2

HCID 12661DiketeneHCID 4082852-Morpholinoethylamine

生成物 1

HCID 4076516N-(2-morpholin-4-ylethyl)-3-oxobutanamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a solution of diketene (23.0 ml) in diethyl ether (115 ml) was added dropwise a solution of N-(2aminoethyl)morpholine (34.7 g) in diethyl ether (300 ml) at -40° C. After stirring for 2 hours at the same condition, the resulting precipitates were collected by filtration and dried in vacuo to give N-(2morpholinoethyl)acetoacetamide (41.1 g).

後処理

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-677f3f25c1d74e48aec7fe1e765794b7
出典データセット
uspto-grants-1989_08
特許番号
US04857527

関連ノート

読み込み中…