4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate → 6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione

反応式

[NH2:1][C:2]([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[CH:3][C:4](OCC)=[O:5].ClC1C(OC(C)C)=CC([N:27]=[C:28]=[O:29])=C(F)C=1>>[F:15][C:9]([F:14])([C:2]1[NH:1][C:28](=[O:29])[NH:27][C:4](=[O:5])[CH:3]=1)[C:10]([F:11])([F:12])[F:13]

参加物

反応物 2

HCID 132729244-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate

HCID 71404335Ethyl 3-amino-4,4,5,5,5-pentafluoropent-2-enoate

生成物 1

HCID 867433186-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione

実験手順

using ethyl 3-amino-4,4,5,5,5-pentafluoro-2-pentenoate and 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate there is obtained 3- 4-chloro-2-fluoro-5-isopropoxyphenyl)-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione, m.p. 141°-143° C.;

出典と根拠

ORDレコード: ord-28059772e7984102956f3da9de4be28f
出典データセット: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04859229

反応ノート

読み込み中…