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4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate → Ethyl 3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-2-methyl-2-pentenoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate | HCID 13272924 | — |
| 反応物 | Ethyl 3-amino-2-methyl-2-pentenoate | HCID 86743319 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-2-methyl-2-pentenoate | HCID 53742260 | — |
反応手順
using 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate in diethyl ether with ethyl 3-amino-2-methyl-2-pentenoate there is obtained ethyl 3-[3-(4-chloro-2-fluoro-5-isopropoxyphenyl)ureido]-2-methyl-2-pentenoate, m.p. 104°-106° C., and from this intermediate with sodium hydride in dimethylformamide there is obtained 6-ethyl-3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5 -methyl-2,4(1H,3H)-pyrimidinedione, m.p. 196°-198° C.:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04859229 |
| 出典データセット | uspto-grants-1989_08 |
| ORD ID | ord-163eb66e38d7440fbc7a6966e69df8c0 |
| 出典メモ | uspto-grants-1989_08 |