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Dicyclohexylcarbodiimide → 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl 3-[piperidino(carbonyl)]propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 4-Oxo-4-(piperidin-1-yl)butanoic acid | HCID 792860 | — |
| 反応物 | 1-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedione | HCID 11267757 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl 3-[piperidino(carbonyl)]propionate | HCID 20026127 | — |
反応手順
using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione and 3-[piperidino(carbonyl)]-propionic acid with N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine as the catalyst in methylene chloride there is obtained 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4 -fluorophenyl 3-[piperidino(carbonyl)]propionate. 1H-NMR (CDC3, 400 MHz): 7.35 ppm (d,1H), 7.20 ppm (d,1H), 6.36 ppm (s,1H), 3.50-3.60 ppm (m,5H), 3.42 ppm (t,2H). 2.94 ppm (t,2H), 2.74 ppm (t,2H), 1.49°-1.70 ppm (m.6H);
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04859229 |
| 出典データセット | uspto-grants-1989_08 |
| ORD ID | ord-c971bb67cbf745db94b0145f78005d6a |
| 出典メモ | uspto-grants-1989_08 |