Water → ethyl N-(4-formyl-2-nitrophenyl)glycine

HRID 1723096ノート

反応式

HRID 1723096 の反応式
Cl.[CH2:2]([NH:4][CH2:5][C:6]([OH:8])=[O:7])[CH3:3].O.F[C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20].C(=O)([O-])O.[Na+]>C(O)C>[CH2:2]([N:4]([C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20])[CH2:5][C:6]([OH:8])=[O:7])[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 5981294-Fluoro-3-nitrobenzaldehydeHCID 19011402N-Ethylglycine--hydrogen chloride (1/1)

生成物 1

HCID 86743322ethyl N-(4-formyl-2-nitrophenyl)glycine収率 79%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(a-1) To a stirred solution of 1.4 parts of ethyl glycine hydrochloride in 10 parts of water was added a solution of 1.7 parts of 4-fluoro-3-nitrobenzaldehyde in 8 parts of ethanol. Then there were added 1.76 parts of sodium hydrogen carbonate and stirring at room temperature was continued for 48 hours. The precipitated product was filtered off, washed successively with water, ethanol and 2,2'-oxybispropane, and dried, yielding 2 parts (79%) of ethyl N-(4-formyl-2-nitrophenyl)-glycine; mp. 90° C. (int. 29).

後処理

  1. filtrationThe precipitated product was filtered off
  2. washwashed successively with water, ethanol and 2,2'-oxybispropane
  3. customdried

出典と根拠

ORDレコード
ord-8b14977da1324c5595970fe82a0ca1ef
出典データセット
uspto-grants-1989_08
特許番号
US04859684

反応ノート

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