2-(Bromomethyl)thiophene → 3-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinone

反応式

[SH:1][C:2]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10](=[O:18])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:20][C:21]1[S:22][CH:23]=[CH:24][CH:25]=1>>[C:12]1([N:11]2[C:10](=[O:18])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]2[S:1][CH2:20][C:21]2[S:22][CH:23]=[CH:24][CH:25]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

反応物 2

HCID 118299782-(Bromomethyl)thiophene

HCID 178515047HCID 178515047、化合物

生成物 1

HCID 145751573-Phenyl-2-(2-thienylmethylthio)-4(3H)-quinazolinone収率 37.4%

実験手順

The title compound was prepared in a yield of 37.4%, using 2-mercapto-3-phenyl-4(3H)-quinazolinone in place of 3-isobutyl-2-mercapto-4(3H)-quinazolinone and 2bromomethylthiophene in place of 2-chloromethylpyridine hydrochloride.

出典と根拠

ORDレコード: ord-5661b0e66b904aba9b6a3bfcb21e017d
出典データセット: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04861780

反応ノート

読み込み中…