HCID 11244270、化合物 → HCID 9851847、化合物
反応式
[Br-].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][N+:12]([CH3:15])=[CH:11][C:10]=2[C:16]([O:18][CH3:19])=[O:17])=[CH:5][CH:4]=1>C(O)C.[Pt]=O>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][C@H:10]2[C:16]([O:18][CH3:19])=[O:17])=[CH:5][CH:4]=1参加物
4
実験手順
4-(4'-Fluorophenyl)-3-methoxycarbonyl-1-methylpyridinium bromide (15.90 g), prepared as in Example 1, in ethanol (250 ml) was hydrogenated at atmospheric pressure and 45° for 24 hours, in the presence of platinum oxide (0.5 g). Evaporation of the filtrate after removing the catalyst gave a dark oil which was partitioned between 10% sodium carbonate solution (100 ml) and dichloromethane (30 ml). After separation, the aqueous phase was extracted with dichloromethane (3×20 ml) and the organic solutions dried (potassium carbonate) and evaporated to give an off-white solid (12.1 g). Crystallisation from ethyl acetate gave the title compound as white crystals (8.32 g, 72%), m.p. 88°-89°.