HCID 9851847、化合物 → (-)-(3S,4R)-4-(4-fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1.C[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1参加物
4
実験手順
(±)-cis-4-(4'-Fluorophenyl)-3-methoxycarbonyl-1-methylpiperidine (2.0 g), prepared as in Example 2(a), in dry toluene was added to sodium methoxide in toluene and refluxed for 7 hours. After cooling to 0° and filtration, evaporation gave the title compound as an oil (1.97 g, 99%), purity 85-90%.
後処理
- temperaturerefluxed for 7 hours
- temperatureAfter cooling to 0°
- filtrationfiltration, evaporation
出典と根拠
- ORDレコード
- ord-a22e1a6eb88243058ccc511309987fc4
- 出典データセット
- uspto-grants-1989_08
- 特許番号
- US04861893
反応ノート
読み込み中…