Hydrochloric Acid → (E)-2-[2-(4-(1H-Imidazol-1-yl)butoxyphenyl)ethenyl]benzothiazole

反応式

Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[S:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[NH:24]1[CH:28]=[CH:27][N:26]=[CH:25]1.Cl>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2/[CH:13]=[CH:14]/[C:15]2[S:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:28]=[CH:27][N:26]=[CH:25]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 795Imidazole

HCID 20025798HCID 20025798、化合物

生成物 1

HCID 20025815(E)-2-[2-(4-(1H-Imidazol-1-yl)butoxyphenyl)ethenyl]benzothiazole収率 46%

実験手順

The named compound was prepared as described in Example 38 starting with (H) of Example 38 (3.0 g, 8.7 mmol) and using imidazole in place of dipropylamine to produce 1.5 g (46% yield) of the named compound as the HCl salt, mp 214°-217° C. IR(KBr): 3400, 1595 cm-1. MS: 376(MH+). 1H NMR (CD3OD): δ 9.01 (s, 1H), 7.88-6.91 (m, 12H), 4.21 (t, J=5.2 Hz, 2H), 3.34 (t, J=5.2 Hz, 2H), 2.25 (m, 4H).

後処理

customThe named compound was prepared

出典と根拠

ORDレコード: ord-ccd776a941ff4271a8fd2b76dbbac8be
出典データセット: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04861897

反応ノート

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