Hydrochloric Acid → HCID 178516554、化合物

HRID 1723566ノート

反応式

HRID 1723566 の反応式
C[C:2](C)([O-:4])C.[K+].[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][C:14]2=[O:22])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)=O.Cl>O.C(O)C>[C:7]1([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[CH:2][OH:4])[C:14]2=[O:22])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 3147871-PhenyloxindoleHCID 23665647Potassium tert-butoxide

生成物 1

HCID 178516554HCID 178516554、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Potassium t-butoxide (1.63 g, 14.5 mmoles) and 5 ml absolute ethanol were heated to 80°. 1-Phenyl-2(1H,3H)-indolone (2.09 g, 10 mmoles) was added, followed by ethyl formate (1.09 ml, 13.5 mmoles). The mixture was heated 5 minutes, cooled to 25°, and the nearly solid mass diluted with 50 ml H2O and crushed ice, acidified to pH 3 with 3N HCl and title product recovered by filtration, 2.2 g, m.p. 192°-195°; m/e 237. cf J. Prakt. Chem. 135: 345-360 (1932); J. Med. Chem. 8: 637 (1965).

後処理

  1. temperatureThe mixture was heated 5 minutes
  2. temperaturecooled to 25°
  3. customcrushed ice

出典と根拠

ORDレコード
ord-7fe51836fd5a459a9c77fab8962ea2b8
出典データセット
uspto-grants-1989_08
特許番号
US04861880

反応ノート

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