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Hydrochloric Acid → 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropionate | HCID 9877912 | — |
| 反応物 | HCID 178418435 | HCID 178418435 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3,3,3-Trifluoro-2-(trifluoromethyl)-1,2-propanediol | HCID 11805677 | 96% |
反応手順
With stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise to a mixture of 25.0 g sodium boron hydride, 500 g water and 500 g diethyl ether. Stirring continued for 10 hours, after which hydrochloric acid was added to quench the reaction. The organic layer was separated, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07485408B2 |
| 出典データセット | uspto-grants-2009_02 |
| ORD ID | ord-581c18f00d20498ebc21c1af0e00e8f8 |
| 出典メモ | uspto-grants-2009_02 |