Acetic Acid → 4-[(3-ethoxy-4-methoxybenzylidene)amino]-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one

HRID 1723654ノート

反応式

HRID 1723654 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH:7]=O)[CH3:2].C(O)(=O)C.[NH2:18][N:19]1[C:24](=[O:25])[C:23]([CH3:26])=[N:22][N:21]=[C:20]1[S:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[F:35]>C(O)C>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH:7]=[N:18][N:19]1[C:24](=[O:25])[C:23]([CH3:26])=[N:22][N:21]=[C:20]1[S:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[F:35])[CH3:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 2447283-Ethoxy-4-methoxybenzaldehydeHCID 71967014-Amino-3-[(2-fluorophenyl)methylsulfanyl]-6-methyl-1,2,4-triazin-5-one

生成物 1

HCID 688502524-[(3-ethoxy-4-methoxybenzylidene)amino]-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
65 °C

実験手順

0.054 g of 3-ethoxy-4-methoxybenzaldehyde and 0.017 ml of acetic acid were added to a solution of 0.080 g of 4-amino-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one in 4 ml of ethanol, and the mixture was stirred at 65° C. The resultant precipitate was filtered off with suction, giving 4-[(3-ethoxy-4-methoxybenzylidene)amino]-3-(2-fluorobenzylsulfanyl)-6-methyl-4H-1,2,4-triazin-5-one.

後処理

  1. filtrationThe resultant precipitate was filtered off with suction

出典と根拠

ORDレコード
ord-1819011266ed44bbb0e0ad592c19e685
出典データセット
uspto-grants-2009_02
特許番号
US07485639B2

反応ノート

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